MEDIACE by Chemisis Pharmaceuticals contains Oxymetazoline Hydrochloride, a topical decongestant used to relieve nasal congestion caused by allergies, colds, or sinusitis. Oxymetazoline is an alpha-adrenergic agonist that works by constricting the blood vessels in the nasal passages, leading to reduced swelling and congestion. The typical dosage of MEDIACE is 2-3 sprays in each nostril twice daily (every 10 to 12 hours), but not more than twice in 24 hours. It is important to use this medication as directed and not to exceed the recommended dosage. Prolonged use (more than 3 days) can lead to rebound congestion, where nasal congestion worsens after stopping the medication. Common side effects of Oxymetazoline nasal solution may include temporary burning, stinging, dryness in the nose, runny nose, and sneezing. Serious side effects are rare but can include increased blood pressure, irregular heartbeat, and severe headache. Patients with heart disease, high blood pressure, thyroid disorders, diabetes, or prostate problems should consult their healthcare provider before using this medication.